Symptoms often include frequent urination, increased thirst, and increased hunger. Control and complications trialepidemiology of diabetes interventions and complications study has meant that millions of people with diabetes may prevent or delay debilitating and often fatal complications from the disease. The niddk funded the landmark diabetes control and complications trial dcct to see if people with type 1 diabetes who kept their blood glucose levels as close to normal as safely possible with intensive diabetes treatment 3 or more shots of insulin per day or an insulin pump with selfmonitoring of blood glucose at least 4 times per day could slow the development of eye. The dcct was among the first and most successful multicenter clinical trials of diabetes run by the national institute. Measurements will be from capillary blood and analyzed as dcctstandard in a central laboratory. Ukpds, dcct diabetes mellitus diabetes mellitus tipo 2.
Francesco cosentino, cardiology unit, department of medicine solna, karolinska institute and karolinska university hospital, solna, 171 76 stockholm, sweden. Descargue como docx, pdf, txt o lea en linea desde scribd. Patients dcct was a multicenter clinical trial, involving patients with type 1 diabetes mellitus, that examined the effects of intensive diabetes therapy. The diabetes control and complications trial dcct is a multicenter, randomized. Ukpds, dcct diabetes mellitus diabetes mellitus tipo 2 scribd. Overview the dcct was designed to test the glucose hypothesis and determine whether the complications of type 1 diabetes could be prevented or delayed 19821993 the edic observational followup study determined the durability of the dcct effects on the moreadvanced stages of diabetes complications including. Intensive diabetes therapy and ocular surgery in type 1 diabetes. Diabetic kidney disease and diabetic nephropathy are the leading cause of endstage kidney disease in the united states and most developed countries. The diabetes control and complications trial dcct and. Dcct intensive diabetes therapy and glomerular filtration. The diabetes control and complications trialepidemiology. If left untreated, diabetes can cause many complications. Diabetes control and complications trial research group. Diabetes can affect many parts of the body and is associated with serious complications, such as heart disease and stroke, blindness, kidney failure, and.
Acute complications can include diabetic ketoacidosis. The increasing use of hba 1c to monitor longterm glycemic control in diabetic patients is largely the result of data from the dcct and the u. The diabetes control and complications trial dcct is a multicenter, randomized, clinical study designed to determine whether an intensive treatment regimen directed at maintaining blood glucose concentrations as close to normal as possible will affect the appearance or progression of early vascular complications in patients with insulindependent diabetes mellitus iddm. Diabetes accounts for 30% to 50% of the incident cases of endstage kidney disease in the united states. The niddk funded the landmark diabetes control and complications trial dcct to see if people with type 1 diabetes who kept their blood glucose levels as close to normal as safely possible with intensive diabetes treatment 3 or more shots of insulin per day or an insulin pump with selfmonitoring of blood glucose at least 4 times per day could slow the development of eye, kidney, and nerve. The diabetes control and complications trial dcct is a multicenter, randomized, clinical study designed to determine whether an intensive treatment regimen directed at maintaining blood glucose concentrations as close to normal as possible will affect the appearance or progression of early vascular complications in patients with insulin. Diabetes control and complications trial epidemiology of. Diabetes mellitus dm, commonly known as diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Aged between 670 years old inclusive at signature of pic children. Authors ordering reprints of their ada journal article will receive a discounted rate. Grant, leeds institute of cardiovascular and metabolic.
The diabetes control and complications trialepidemiology of diabetes interventions and complications research group. Reprints can be ordered in black and white or color and are available for purchase in quantities of at least 100. The new england journal of medicine 2644 n engl j med 353. The effect of intensive treatment of diabetes on the development and progression of longterm complications in insulindependent diabetes mellitus. This does sound expensive, but when the cost of treatment for people with established diabetes complications is compared to the cost of prevention by intensive treatment ie, at least four blood glucose tests per day as in the dcct, the selfcare group. Its not that simple, and some of the data are still elusive. But if we pay attention to microvascular complications, as was seen in the diabetes control and complications trial dcct in people with type 1 diabetes, there is no question that theres a significant reduction in microvascular disease. Reprints are printed copies of a published article s. The epidemiology of diabetes interventions and complications edic observational followup determined the durability of the dcct effects on the more. Objective the diabetes control and complications trial dcct was designed to test the glucose hypothesis and determine whether the complications of type 1 diabetes t1dm could be prevented or delayed. Summary of the dcctedic study the diabetes control and complications trial dcct, 198293 and the epidemiology of diabetes interventions and complications edic, 19942006 followup study have been ongoing for more than twenty years. Although this represents a significant public health concern, it is important to note that only 30% to 40% of patients with. The epidemiology of diabetes interventions and complications edic observational followup determined the durability of the dcct effects on the moreadvanced stages of diabetes complications.
490 1435 454 626 1187 1047 58 127 1580 1458 376 1480 48 1465 265 255 1136 1461 808 916 1401 773 1363 1342 293 1086 558 1157 71 47 689